Cash and cash equivalents
Cash And Cash Equivalents, At Carrying Value, Rounded
Cash And Cash Equivalents, At Carrying Value, Rounded
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
Variable Rate [Domain]
Variable Rate [Domain]
Pay vs Performance Disclosure [Line Items]
Schedule of Accrued Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Accrued liabilities (Note 6)
Accrued Liabilities, Current
Statistical Measurement
Statistical Measurement [Domain]
Research and development
Research and Development Expense
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Expiration period from date of grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Award Type
Award Type [Domain]
Fair Value as of Grant Date
Award Grant Date Fair Value
Outstanding and unvested, beginning balance (in shares)
Outstanding and unvested, ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Debt Draw, Tranche Two
Debt Draw, Tranche Two [Member]
Debt Draw, Tranche Two
Released (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Releases in Period
Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Releases in Period
Long-term Debt
Debt Disclosure [Text Block]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
2020 Stock Options and Incentive Plan and 2022 Inducement Plan
Two Thousand And Twenty Stock Options And Incentive Plan And Two Thousand Twenty Two Inducement Plan [Member]
Two Thousand And Twenty Stock Options And Incentive Plan And Two Thousand Twenty Two Inducement Plan
Schedule of Money Market Funds, U.S. Government Agency Securities and Corporate Debt Securities by Significant Investment Category
Cash, Cash Equivalents and Investments [Table Text Block]
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Accounts payable
Accounts Payable, Current
Weighted- average remaining contractual term (in years), exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Restatement Determination Date:
Restatement Determination Date [Axis]
Performance-Based Restricted Stock Units, TSR Goal
Performance-Based Restricted Stock Units, TSR Goal [Member]
Performance-Based Restricted Stock Units, TSR Goal
Corporate debt securities
Corporate Debt Securities [Member]
Commitments and Contingencies (Note 13)
Commitments and Contingencies
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Insider Trading Policies and Procedures [Line Items]
Number of options, exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
Interest and other income (expense), net
Interest and Other Income (Expense), Net
Interest and Other Income (Expense), Net
Payment of offering costs
Payments Of Deferred Offering Costs
Represents the payments of deferred offering costs.
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Preferred Stock
Common Stock
Equity [Text Block]
Aggregate intrinsic value, vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Geographical
Geographical [Axis]
Shares of common stock available for future grants under the 2020 Stock Option and Incentive Plan
Two Thousand And Twenty Stock Options And Incentive Plan [Member]
2020 Stock options and incentive plan.
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Prepaid licenses
Prepaid Licenses, Current
Prepaid Licenses, Current
Income Taxes
Income Tax Disclosure [Text Block]
Organization and Description of Business
Business Description and Basis of Presentation [Text Block]
Underlying common stock fair value (USD per share)
Underlying Common Stock Fair Value
Underlying common stock fair value.
Expected dividend
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Liabilities measured at fair value
Financial Liabilities Fair Value Disclosure
Current liabilities
Liabilities, Current [Abstract]
Preferred stock, par value (USD per share)
Preferred Stock, Par or Stated Value Per Share
Preferred stock, $0.0001 par value per share; 10,000,000 shares authorized at March 31, 2024 and December 31, 2023, and none issued or outstanding at March 31, 2024 and December 31, 2023 (Note 9)
Preferred Stock, Value, Issued
Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Employee stock purchase plan, description
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award
Incentive Stock Options and Nonqualified Stock Options
Incentive Stock Options And Nonqualified Stock Options [Member]
Incentive stock options and nonqualified stock options.
Diluted (USD per share)
Earnings Per Share, Diluted
Accretion of final payment
Long-Term Debt, Accretion Of Final Payment
Long-Term Debt, Accretion Of Final Payment
Net unrealized (loss) gain on short-term investments
Unrealized Gain (Loss) on Investments
Stock options and ESPP
Employee Stock Option And Purchase Plan [Member]
Employee stock option and purchase plan.
PEO Total Compensation Amount
PEO Total Compensation Amount
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Weighted- average exercise price per share, vested and expected to vest (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Fair Value, Inputs, Level 3
Fair Value, Inputs, Level 3 [Member]
Correlation coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions ; Correlation Coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions ; Correlation Coefficient
Outstanding, beginning balance (in shares)
Outstanding, ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Trading Symbol
Trading Symbol
2029 and thereafter
Lessee, Operating Lease, Liability, To Be Paid, Year Four And After Year Four
Lessee, Operating Lease, Liability, To Be Paid, Year Four And After Year Four
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Granted (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Grant date fair value of stock option (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Net loss
Net loss
Net Income (Loss)
Net Income (Loss)
Total current liabilities
Liabilities, Current
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Company Selected Measure Name
Company Selected Measure Name
Accounting Standards Update and Change in Accounting Principle [Table]
Accounting Standards Update and Change in Accounting Principle [Table]
Leases
Lessee, Operating Leases [Text Block]
Novartis Agreement
Novartis Agreement [Member]
Novartis agreement.
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Axis]
Stockholders’ equity
Equity, Attributable to Parent [Abstract]
Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Schedule of Weighted-average Remaining Lease Terms and Discount Rates
Assets And Liabilities, Lessee [Table Text Block]
Assets And Liabilities, Lessee
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Executive Category:
Executive Category [Axis]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Performance Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Exercised (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Level 1
Fair Value, Inputs, Level 1 [Member]
Name
Measure Name
Name
Forgone Recovery, Individual Name
Purchase of short-term investments
Payments to Acquire Short-Term Investments
Schedule of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Equity Components
Equity Components [Axis]
Financial Instruments [Domain]
Financial Instruments [Domain]
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Accrued liabilities
Increase (Decrease) in Accrued Liabilities
Valuation date share price (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Lessee, Lease, Description [Table]
Lessee, Lease, Description [Table]
Options granted (in shares)
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Underlying Securities
Award Underlying Securities Amount
Entity Small Business
Entity Small Business
Local Phone Number
Local Phone Number
Accounts receivable
Increase (Decrease) in Accounts Receivable
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Letter of Credit
Letter of Credit [Member]
Forecast
Forecast [Member]
Dividends declared (USD per share)
Common Stock, Dividends, Per Share, Declared
Net unrealized (loss) gain on short-term investments
Net unrealized (loss) gain on short-term investments
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Average peer group correlation coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Correlation Coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Correlation Coefficient
Number of classes of stock authorized
Number Of Classes Of Stock Authorized
Number Of Classes Of Stock Authorized
Measurement Frequency
Measurement Frequency [Axis]
Operating lease liabilities, non-current (Note 14)
Total operating lease liabilities non-current
Operating Lease, Liability, Noncurrent
Released (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Released, Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Released, Weighted Average Grant Date Fair Value
Vesting of RSUs
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Depreciation expense
Depreciation
Retirement Benefits [Abstract]
Retirement Benefits [Abstract]
Income Statement Location
Income Statement Location [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Issuance of common stock under benefit plans (in shares)
Stock Issued During Period, Shares, Employee Benefit Plan
U.S. Government agency securities
US Government Corporations and Agencies Securities [Member]
Temporary Equity Disclosure [Abstract]
Temporary Equity Disclosure [Abstract]
Schedule of Operating Lease Liability
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Initial public offering, shares issued (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Revenues
Revenues
2015 Equity and 2020 Incentive Plan
Two Thousand Fifteen And Two Thousand Twenty Equity Incentive Plan [Member]
Two thousand fifteen and two thousand twenty equity incentive plan .
Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Other Performance Measure, Amount
Other Performance Measure, Amount
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Schedule of Operating and Variable Lease Cost
Lease, Cost [Table Text Block]
Research and development expenses
Research and Development Expense [Member]
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Total
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Award Type
Award Type [Axis]
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Plan Name
Plan Name [Domain]
Document Quarterly Report
Document Quarterly Report
Interest expense
Interest expense
Interest Expense
Purchase of property and equipment in accounts payable and accrued liabilities
Capital Expenditures Incurred but Not yet Paid
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
General and administrative expenses
General and Administrative Expense [Member]
Total property and equipment, gross
Property, Plant and Equipment, Gross
Weighted- average remaining contractual term (in years), outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Right-of-use assets obtained in exchange for new operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Trading Arrangement:
Trading Arrangement [Axis]
Less: Present value discount
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Long-term Debt, Type [Domain]
Long-Term Debt, Type [Domain]
Entity File Number
Entity File Number
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Restricted Stock Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Operating lease liabilities, current (Note 14)
Total operating lease liabilities current
Operating Lease, Liability, Current
2028
Long-Term Debt, Maturity, Year Three
Entity Shell Company
Entity Shell Company
2027
Lessee, Operating Lease, Liability, to be Paid, Year Three
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Recently Announced Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Restatement Determination Date
Restatement Determination Date
Counterparty Name
Counterparty Name [Domain]
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Cash and cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Total cash, cash equivalents, and restricted cash shown in the statements of cash flows
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
2026
Lessee, Operating Lease, Liability, to be Paid, Year Two
Share price of shares issued in initial public offering (USD per share)
Sale of Stock, Price Per Share
Private Placement
Private Placement [Member]
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Other variable costs
Variable Lease, Cost
Operating lease costs
Operating Lease, Cost
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Schedule of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for Stock Option Awards
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Security Exchange Name
Security Exchange Name
Assets measured at fair value
Assets, Fair Value Disclosure
Long-term debt (Note 7)
Total
Long-Term Debt
Proceeds from the initial public offering
Sale of Stock, Consideration Received on Transaction
2029
Long-Term Debt, Maturity, Year Four
Accumulated other comprehensive (loss) gain
Accumulated Other Comprehensive Income (Loss), Net of Tax
Vesting rights, percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Novartis Collaboration and License Agreement ("the Novartis Agreement")
Collaborative Arrangement Disclosure [Text Block]
Outstanding stock option awards
Options to purchase common stock
Stock Options
Employee Stock Option [Member]
Interest receivable
Interest Receivable, Current
Unrecognized compensation expense, weighted average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Maximum
Maximum [Member]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Vesting of PSUs*
Performance Stock Units [Member]
Performance Stock Units
Document Type
Document Type
Underwriters
Underwriters [Member]
Underwriters
Tabular List, Table
Tabular List [Table Text Block]
Entity Address, Address Line One
Entity Address, Address Line One
Total accrued liabilities
Accrued Liabilities and Other Liabilities
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Equity Incentive Plans and Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Weighted- Average Exercise Price per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Accrued research and development
Accrued Research And Development Expenses, Current
Accrued research and development expenses, current
Percentage of payroll deductions
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Restricted cash
Restricted Cash, Noncurrent
Variable Rate [Axis]
Variable Rate [Axis]
Income Statement [Abstract]
Income Statement [Abstract]
Common stock issued in a public offering, net of offering expenses (in shares)
Stock Issued During Period, Shares, New Issues
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Title of 12(b) Security
Title of 12(b) Security
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Related Party
Related Party, Type [Domain]
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Unvested and outstanding, beginning balance (USD per share)
Unvested and outstanding, ending balance (USD per share)
Weighted-average grant date fair value, outstanding and unvested (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Supplemental disclosures of cash flow information:
Supplemental Cash Flow Disclosures [Abstract]
Supplemental Cash Flow Disclosures Abstract
Class of Stock [Line Items]
Class of Stock [Line Items]
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Stated interest rate plus variable rate floor
Debt Instrument, Stated Interest Rate Plus Variable Rate
Debt Instrument, Stated Interest Rate Plus Variable Rate
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Entity Tax Identification Number
Entity Tax Identification Number
Novartis
Novartis [Member]
Novartis.
Total expense
Lease, Cost
Statistical Measurement
Statistical Measurement [Axis]
Financial Instrument [Axis]
Financial Instrument [Axis]
Entity Interactive Data Current
Entity Interactive Data Current
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Total Shareholder Return Amount
Total Shareholder Return Amount
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Supplemental disclosures of noncash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Landlord
Landlord [Member]
Landlord
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Measure:
Measure [Axis]
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Name
Outstanding Recovery, Individual Name
Term loan facility
Debt Instrument, Face Amount
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Current assets
Assets, Current [Abstract]
Leases [Abstract]
Leases [Abstract]
Other accrued liabilities
Accounts Payable and Other Accrued Liabilities, Current
Entity Address, State or Province
Entity Address, State or Province
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Counterparty Name
Counterparty Name [Axis]
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Schedule of Classification of Stock-based Compensation Expense
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions [Table Text Block]
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
PEO
PEO [Member]
Average peer group volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Volatility
Supplemental disclosures of cash flow information related to leases:
Additional Cash Flow Elements and Supplemental Cash Flow Information [Abstract]
California
CALIFORNIA
Cash Equivalents
Cash Equivalents [Member]
Common stock, par value (USD per share)
Common Stock, Par or Stated Value Per Share
Sale of Stock
Sale of Stock [Axis]
Net cash used in (provided by) investing activities
Net Cash Provided by (Used in) Investing Activities
Number of Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Debt Instrument [Axis]
Debt Instrument [Axis]
Shares of common stock available for future issuance under the 2022 Inducement Plan
Two Thousand And Twenty Two Inducement Plan [Member]
Two Thousand And Twenty Two Inducement Plan
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Effective tax rate
Effective Income Tax Rate Reconciliation, Percent
Operating lease, liability
Operating Lease, Liability
Line of credit, amount subject to lender's discretion
Line Of Credit, Amount Subject To Lender's Discretion
Line Of Credit, Amount Subject To Lender's Discretion
Credit Facility [Axis]
Credit Facility [Axis]
Outstanding amount threshold, maximum collateral requirement
Debt Instrument, Covenant, Outstanding Amount Threshold, Maximum Collateral Requirement
Debt Instrument, Covenant, Outstanding Amount Threshold, Maximum Collateral Requirement
Schedule of Maturities of Long-Term Debt
Schedule of Maturities of Long-Term Debt [Table Text Block]
Total liabilities
Liabilities
Volatility
Expected stock price volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Accumulated Other Comprehensive Gain/(Loss)
AOCI Attributable to Parent [Member]
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Payment made under defined contribution plan
Defined Contribution Plan, Cost
Total shares reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Measurement Frequency
Measurement Frequency [Domain]
Property and Equipment, net
Property, Plant and Equipment Disclosure [Text Block]
All Executive Categories
All Executive Categories [Member]
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Plan Name
Plan Name [Axis]
Accrued Liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Debt Disclosure [Abstract]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
Subsequent To Second Anniversary
Subsequent To Second Anniversary [Member]
Subsequent To Second Anniversary
Common stock, $0.0001 par value per share; 300,000,000 shares authorized at March 31, 2024 and December 31, 2023; and 60,318,542 and 59,921,002 shares issued and outstanding at March 31, 2024 and December 31, 2023, respectively; (Note 10)
Common Stock, Value, Issued
General and administrative
General and Administrative Expense
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Non-cash operating lease expense
Operating Lease, Right-of-Use Asset, Periodic Reduction
Thereafter
Long-Term Debt, Maturity, After Year Four
Long-Term Debt, Maturity, After Year Four
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Total current assets
Assets, Current
Restricted cash
Restricted Cash
All Individuals
All Individuals [Member]
Entity Filer Category
Entity Filer Category
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Statement [Table]
Statement [Table]
Current Fiscal Year End Date
Current Fiscal Year End Date
PEO Name
PEO Name
Expected volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Number of integrin research targets
Number Of Integrin Research Targets
Number of Integrin research targets.
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Granted (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Issuance of common stock under benefit plans
Stock Issued During Period, Value, Employee Benefit Plan
Prepaid insurance
Prepaid Insurance
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Aggregate intrinsic value, exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Fair Value Measurements, Non-recurring Basis
Fair Value, Nonrecurring [Member]
Furniture and fixtures
Furniture and Fixtures [Member]
Stated percentage
Debt Instrument, Interest Rate, Stated Percentage
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
Term Loan Facility
Term Loan Facility [Member]
Term Loan Facility
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Total stockholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Leased premises under non cancelable operating lease
Leased Space Under Non Cancellable Operating Lease
Leased space under non cancellable operating lease.
Maturity of short-term investments
Proceeds from Maturities, Prepayments and Calls of Short-Term Investments
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Expected term (in years)
Expected term of options (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Level 2
Fair Value, Inputs, Level 2 [Member]
Entity Emerging Growth Company
Entity Emerging Growth Company
First Anniversary
First Anniversary [Member]
First Anniversary
Effective interest rate for the term loan
Debt Instrument, Interest Rate, Effective Percentage
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Document Fiscal Period Focus
Document Fiscal Period Focus
2025
Lessee, Operating Lease, Liability, to be Paid, Year One
Line of credit facility, remaining borrowing capacity
Line of Credit Facility, Remaining Borrowing Capacity
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Antidilutive Securities
Antidilutive Securities [Axis]
2028
Lessee, Operating Lease, Liability, to be Paid, Year Four
Prepaid research and development
Prepaid Research And Development, Current
Prepaid Research And Development, Current
Title
Trading Arrangement, Individual Title
Outstanding, beginning balance (USD per share)
Outstanding, ending balance (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Common Stock
Common Stock [Member]
Individual:
Individual [Axis]
City Area Code
City Area Code
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Net Loss Per Share Attributable to Common Stockholders
Earnings Per Share [Text Block]
Income Statement Location
Income Statement Location [Domain]
Document Fiscal Year Focus
Document Fiscal Year Focus
Geographical
Geographical [Domain]
Lease term
Lessee, Operating Lease, Term of Contract
Performance-based restricted stock units
Performance-Based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units
Minimum
Minimum [Member]
Debt Draw Period [Axis]
Debt Draw Period [Axis]
Debt Draw Period
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Property and equipment, net
Total property and equipment, net
Property, Plant and Equipment, Net
Schedule of Option Activity Under the 2015 Plan and 2020 Plan
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Exercise Price
Award Exercise Price
Dividends paid (USD per share)
Common Stock, Dividends, Per Share, Cash Paid
Accrued Liabilities and Other Liabilities [Abstract]
Accrued Liabilities and Other Liabilities [Abstract]
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Assets
Assets [Abstract]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Common stock, voting rights, number of votes per share
Number Of Votes Per Share Of Common Stock
Number Of Votes Per Share Of Common Stock
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
U.S. Treasury securities
US Treasury Securities [Member]
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Lessee, Lease, Description [Line Items]
Lessee, Lease, Description [Line Items]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Accumulated Deficit
Retained Earnings [Member]
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Net amortization (accretion) on short-term investments and debt
Accretion (Amortization) of Discounts and Premiums, Investments
Total liabilities and stockholders’ equity
Liabilities and Equity
Adjusted Cost
Debt Securities, Available-for-Sale, Amortized Cost
Other non-current assets
Other Assets, Noncurrent
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Basic (USD per share)
Earnings Per Share, Basic
Operating lease right-of-use assets (Note 14)
Operating Lease, Right-of-Use Asset
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Schedule of Long-Term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
Sale of Stock
Sale of Stock [Domain]
Risk-free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Expected volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Interest rate in case of default
Debt Instrument, Interest Rate In Case Of Default
Debt Instrument, Interest Rate In Case Of Default
2024 (remainder of the year)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Arrangement Duration
Trading Arrangement Duration
Entity Address, City or Town
Entity Address, City or Town
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Amount undrawn
Debt Instrument, Amount Undrawn
Debt Instrument, Amount Undrawn
Weighted- average remaining contractual term (in years), vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Public Offering
Public Offering [Member]
Public Offering
Public Offering And Private Placement
Public Offering And Private Placement [Member]
Public Offering And Private Placement
Proceeds from term loan, net
Proceeds from term loan, net of issuance costs
Proceeds from Issuance of Debt
Document Transition Report
Document Transition Report
Award Timing Predetermined
Award Timing Predetermined [Flag]
Termination Date
Trading Arrangement Termination Date
Accounts payable
Increase (Decrease) in Accounts Payable
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Market Value
Debt Securities, Available-for-Sale
Line of Credit Facility, Lender [Domain]
Line of Credit Facility, Lender [Domain]
Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Short-term investments
Short-Term Investments [Member]
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Total payments
Long-Term Debt, Gross
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
All Trading Arrangements
All Trading Arrangements [Member]
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Award Timing Disclosures [Line Items]
Common stock shares outstanding percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Compensation Amount
Outstanding Recovery Compensation Amount
Schedule of Shares Reserved for Future Issuance
Schedule Of Common Stock Reserved For Future Issuance Table [Table Text Block]
Schedule of common stock reserved for future issuance.
Forfeited (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Employee stock purchase plan offering period
Employee Stock Purchase Plan Offering Period
Employee stock purchase plan offering period.
Forfeited (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Prepaid expenses and other current assets (Note 5)
Total prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Shares of common stock available for future issuance under the 2020 Employee Stock Purchase Plan
2020 Employee Stock Purchase Plan
Two Thousand And Twenty Employee Stock Purchase Plan [Member]
Two thousand and twenty employee stock purchase plan.
Forfeited (in shares)
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Period in which options may be granted
Share Based Compensation Options Under Plan May Be Granted For Periods
Share based compensation options under plan may be granted for periods.
Debt Instrument, Redemption, Period [Domain]
Debt Instrument, Redemption, Period [Domain]
Insider Trading Arrangements [Line Items]
Computer equipment and software
Computer Equipment And Software [Member]
Computer equipment and software.
Related Party
Related Party, Type [Axis]
Aggregate intrinsic value, outstanding balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Entity Registrant Name
Entity Registrant Name
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
Award Timing Method
Award Timing Method [Text Block]
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Document Period End Date
Document Period End Date
Line of credit facility, current borrowing capacity
Proceeds from Lines of Credit
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Adoption Date
Trading Arrangement Adoption Date
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Weighted- average exercise price per share, exercisable (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Prepayment fee percentage
Debt Instrument, Prepayment Fee Percentage
Debt Instrument, Prepayment Fee Percentage
Entity Central Index Key
Entity Central Index Key
Percent of outstanding shares, shares added per year to plan
Percent Of Outstanding Shares, Shares Added Per Year To Plan
Percent Of Outstanding Shares, Shares Added Per Year To Plan
Debt Instrument, Stated Interest Rate
Debt Instrument, Stated Interest Rate [Member]
Debt Instrument, Stated Interest Rate
Total stock-based compensation expense
Share-Based Payment Arrangement, Expense
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Income tax provision
Income Tax Expense (Benefit)
Reconciliation of cash, cash equivalents, and restricted cash reported in the balance sheets
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations [Abstract]
Accrued compensation and benefits
Employee-related Liabilities, Current
Valuation allowance as a percentage on total deferred tax assets
Valuation Allowance As Percentage On Deferred Tax Assets
Valuation allowance as percentage on deferred tax assets.
Financial Instruments
Fair Value Disclosures [Text Block]
Name
Trading Arrangement, Individual Name
Total other comprehensive (loss) gain
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Lender Name [Axis]
Lender Name [Axis]
Common stock issued in a public offering, net of offering expenses
Stock Issued During Period, Value, New Issues
Equity [Abstract]
Equity [Abstract]
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Weighted-average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Proceeds from issuances of common stock under benefit plans
Proceeds From Issuances Of Common Stock Under Benefit Plans
Proceeds From Issuances Of Common Stock Under Benefit Plans
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
Long-term Debt, Type [Axis]
Long-Term Debt, Type [Axis]
Amendment Flag
Amendment Flag
Money Market Funds
Money Market Funds [Member]
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Schedule of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for 2020 Employee Stock Purchase Plan
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Common stock fair market value percentage
Common Stock Fair Market Value Percentage
Common stock fair market value percentage .
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activities
Number of common stock issued (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Credit Facility [Domain]
Credit Facility [Domain]
Exercise price as a percentage of estimated grant date fair value of shares
Share Based Compensation Arrangement By Share Based Payment Award Exercise Price With Purchase Price Of Common Stock Percentage Of Estimated Grant Date Fair Value For Shareholders
Share based compensation arrangement by share based payment award exercise price with purchase price of common stock percentage of estimated grant date fair value for shareholders.
Variable rate
Debt Instrument, Basis Spread on Variable Rate
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Leasehold improvements
Leasehold Improvements [Member]
Shares used in computing net loss per share - diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Debt Draw Period [Domain]
Debt Draw Period [Domain]
Debt Draw Period [Domain]
Operating expenses:
Operating Expenses [Abstract]
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Company Selected Measure Amount
Company Selected Measure Amount
Additional paid-in capital
Additional Paid in Capital, Common Stock
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Total assets
Assets
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Cover [Abstract]
Cover [Abstract]
Second Anniversary
Second Anniversary [Member]
Second Anniversary
Laboratory equipment
Equipment [Member]
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Text Block]
Prepaid Expenses And Other Current Assets
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Other
Other Prepaid Expense, Current
Fair Value, Recurring
Fair Value, Recurring [Member]
Defined Contribution Plan
Defined Contribution Plan [Text Block]
Non-NEOs
Non-NEOs [Member]
Future lease payments
Total undiscounted lease payments
Lessee, Operating Lease, Liability, to be Paid
Short-term investments
Short-Term Investments
Construction-in-progress
Construction in Progress [Member]
Total operating expenses
Operating Expenses
Net increase in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Non-PEO NEO
Non-PEO NEO [Member]
Lease term extension period
Lessee, Operating Lease, Renewal Term
Equity Component
Equity Component [Domain]
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Loan Agreement
Loan Agreement [Member]
Loan Agreement
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Scenario [Axis]
Scenario [Axis]
Shares used in computing net loss per share - basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Entity Current Reporting Status
Entity Current Reporting Status
Less: unamortized debt issuance costs
Unamortized Debt Issuance Expense
Debt instrument final payment, percentage of original principal amount drawn
Debt Instrument Final Payment, Percentage Of Original Principal Amount Drawn
Debt Instrument Final Payment, Percentage Of Original Principal Amount Drawn
Loss from operations
Operating Income (Loss)
Proceeds from sale of common stock in a public offering
Proceeds from Issuance Initial Public Offering
Pliant Therapeutics
Pliant Therapeutics [Member]
Pliant Therapeutics
Contractual arrangements cancellation period
Contractual Arrangements Cancellation Period
Contractual arrangements cancellation period.
Comprehensive loss:
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Statement [Line Items]
Statement [Line Items]
Number of options, vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Scenario [Domain]
Scenario [Domain]
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Line of credit
Long-Term Line of Credit
Schedule of Prepaid Expenses and Other Current Assets
Schedule Of Prepaid Expenses And Other Current Assets [Table Text Block]
Schedule Of Prepaid Expenses And Other Current Assets