Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Total lease payments
Lessee, Operating Lease, Liability, to be Paid
Related Party Transactions [Abstract]
Related Party Transactions [Abstract]
Outstanding debt
Total
Long-Term Debt, Gross
Maturity of short-term investments
Proceeds from Maturities, Prepayments and Calls of Short-Term Investments
Collaboration and license agreement, integrin research targets amount (up to)
Collaboration And License Agreement Integrin Research Targets Amount
Collaboration and license agreement integrin research targets amount.
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Debt Draw, Tranche Two
Debt Draw, Tranche Two [Member]
Debt Draw, Tranche Two
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
2024
Long-Term Debt, Maturity, Year Two
Tranche one amount undrawn
Debt Instrument, Tranche One Amount Undrawn
Debt Instrument, Tranche One Amount Undrawn
Debt Instrument [Axis]
Debt Instrument [Axis]
Total property and equipment
Property, Plant and Equipment, Gross
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Summary of Money Market Funds, U.S. Government Agency Securities and Corporate Debt Securities by Significant Investment Category
Cash, Cash Equivalents and Investments [Table Text Block]
Performance-Based Restricted Stock Units, TSR Goal
Performance-Based Restricted Stock Units, TSR Goal [Member]
Performance-Based Restricted Stock Units, TSR Goal
Reclassification of restricted stock awards from liabilities to common stock upon vesting
Reclassification Of Restricted Stock Awards From Liabilities To Common Stock Upon Vesting
Reclassification of restricted stock awards from liabilities to common stock upon vesting.
Description of customer payment terms
Revenue, Performance Obligation, Description of Payment Terms
Interest and other income (expense), net
Interest and Other Income (Expense), Net
Interest and Other Income (Expense), Net
Financial Instruments [Domain]
Financial Instruments [Domain]
Loan agreement interest rate
Debt Instrument, Basis Spread on Variable Rate
Statistical Measurement
Statistical Measurement [Domain]
Depreciation expense
Depreciation
Proceeds term loan, net of issuance costs
Proceeds from Issuance of Debt
Option exercises (in shares)
Number of Options, Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Vesting of restricted stock awards (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Shares of common stock available for future grants under the 2020 Stock Option and Incentive Plan
Two Thousand And Twenty Stock Options And Incentive Plan [Member]
2020 Stock options and incentive plan.
Prepaid licenses
Prepaid Licenses, Current
Prepaid Licenses, Current
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Underlying common stock fair value (USD per share)
Underlying Common Stock Fair Value
Underlying common stock fair value.
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Additional paid-in capital
Additional Paid in Capital, Common Stock
Valuation date share price (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Federal
Domestic Tax Authority [Member]
Accounting Policies [Line Items]
Accounting Policies [Line Items]
Accounting policies.
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table]
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Lessee, Lease, Description [Table]
Lessee, Lease, Description [Table]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Summary of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for 2020 Employee Stock Purchase Plan
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Total
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Incentive Stock Options and Nonqualified Stock Options
Incentive Stock Options And Nonqualified Stock Options [Member]
Incentive stock options and nonqualified stock options.
Accretion of final payment
Long-Term Debt, Accretion Of Final Payment
Long-Term Debt, Accretion Of Final Payment
Schedule of Maturities of Long-Term Debt
Schedule of Maturities of Long-Term Debt [Table Text Block]
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Stock options and ESPP
Employee Stock Option And Purchase Plan [Member]
Employee stock option and purchase plan.
Operating Leases, After Adoption of 842:
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Tax Period
Tax Period [Domain]
Prepaid insurance
Prepaid Insurance
Equity Component
Equity Component [Domain]
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Fair Value Measurements, Non-recurring Basis
Fair Value, Nonrecurring [Member]
Earnings Per Share Reconciliation [Abstract]
Earnings Per Share Reconciliation [Abstract]
Correlation coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions ; Correlation Coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions ; Correlation Coefficient
Assets measured at fair value
Assets, Fair Value Disclosure
Additions based on tax positions related to current year
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Vesting rights, percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Leases
Lessee, Operating Leases [Text Block]
Lessee, Lease, Description [Line Items]
Lessee, Lease, Description [Line Items]
Related Party
Related Party [Domain]
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Plan Name
Plan Name [Axis]
Contract assets
Contract with Customer, Asset, after Allowance for Credit Loss
Market Value
Debt Securities, Available-for-Sale
Weighted- Average Exercise Price per Share, Forfeited (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Novartis Agreement
Novartis Agreement [Member]
Novartis agreement.
Number of operating segments
Number of Operating Segments
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Plan Name
Plan Name [Domain]
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Level 1
Fair Value, Inputs, Level 1 [Member]
Weighted- Average Remaining Contractual Term (in Years), Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Schedule of Weighted-average Remaining Lease Terms and Discount Rates
Assets And Liabilities, Lessee [Table Text Block]
Assets And Liabilities, Lessee
Award Type
Award Type [Axis]
Third Rock Ventures
Third Rock Ventures [Member]
Third Rock Ventures.
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Lease liabilities, current
Total current operating lease liabilities
Operating Lease, Liability, Current
Related Party Transaction
Related Party Transaction [Domain]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Number of Options, Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Document Annual Report
Document Annual Report
Total liabilities
Liabilities
Novartis Agreement RD For Integrin Research Targets
Novartis Agreement RD For Integrin Research Targets [Member]
Novartis Agreement RD For Integrin Research Targets
Weighted-average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Geographical
Geographical [Axis]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Average peer group correlation coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Correlation Coefficient
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Correlation Coefficient
Issuance of common stock upon initial public offering/private placement
Stock Issued During Period, Value, New Issues
Aggregate fair value of restricted stock awards vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Schedule of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Revenue Recognition
Revenue from Contract with Customer [Policy Text Block]
Document Type
Document Type
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
Property, plant and equipment, useful life
Property, Plant and Equipment, Useful Life
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Weighted-Average Grant Date fair value, Outstanding and unvested, beginning balance (USD per share)
Weighted-Average Grant Date fair value, Outstanding and unvested, ending balance (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Debt Disclosure
Debt Disclosure [Text Block]
Product and Service
Product and Service [Domain]
Entity Shell Company
Entity Shell Company
Accrued liabilities
Increase (Decrease) in Accrued Liabilities
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Short-term Investments [Abstract]
Short-Term Investments [Abstract]
Financial Instrument [Axis]
Financial Instrument [Axis]
2015 Equity and 2020 Incentive Plan
Two Thousand Fifteen And Two Thousand Twenty Equity Incentive Plan [Member]
Two thousand fifteen and two thousand twenty equity incentive plan .
2025
Long-Term Debt, Maturity, Year Three
Subsequent Event
Subsequent Event [Member]
Document Period End Date
Document Period End Date
Interest receivable
Interest Receivable, Current
Grant date fair value of stock option
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Fair Value
Share based compensation arrangement by share based payment award options grants in period fair value.
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Total assets
Assets
Debt Disclosure [Abstract]
Net loss per share, attributable to common stockholders:
Earnings Per Share [Abstract]
Income Statement Location
Income Statement Location [Axis]
Antidilutive Securities
Antidilutive Securities [Axis]
Numerator
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
2027
Lessee, Operating Lease, Liability, to be Paid, Year Five
Weighted- Average Exercise Price per Share, Exercised (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Forfeited (in shares)
Shares Issued, Shares, Share-Based Payment Arrangement, Forfeited
Accrued compensation and benefits
Employee-related Liabilities, Current
Variable lease payments
Variable Lease, Cost
Stockholders’ equity
Stockholders' Equity Attributable to Parent [Abstract]
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Net Loss Per Share Attributable to Common Stockholders
Earnings Per Share [Text Block]
Summary of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for Stock Option Awards
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Base rent abated amount
Base Rent Abated Amount
Base rent abated amount.
Mature in 1 to 2 years
Mature In One To Two Years [Member]
Mature in one to two years.
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Short Term Investments
Short-Term Investments [Member]
Award Type
Award Type [Domain]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Unrecognized compensation expense, weighted average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted- Average Remaining Contractual Term (in Years), Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Tax credit receivable
Income Taxes Receivable, Current
Entity Registrant Name
Entity Registrant Name
Issuance of common stock upon initial public offering/private placement (in shares)
Stock Issued During Period, Shares, New Issues
Subsequent Events
Subsequent Events [Text Block]
Expected dividends
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Entity Address, City or Town
Entity Address, City or Town
Leases [Abstract]
Leases [Abstract]
Operating expenses:
Operating Expenses [Abstract]
Performance Stock Units
Performance Stock Units [Member]
Performance Stock Units
Vesting of restricted stock awards
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Net operating losses
Deferred Tax Assets, Operating Loss Carryforwards
Underwriters
Underwriters [Member]
Underwriters.
Minimum
Minimum [Member]
Proceeds term loan, net of issuance costs
Proceeds from Debt, Net of Issuance Costs
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Entity Emerging Growth Company
Entity Emerging Growth Company
Common stock, par value (USD per share)
Common Stock, Par or Stated Value Per Share
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Auditor Name
Auditor Name
Financial Instruments
Fair Value Disclosures [Text Block]
Net operating losses
Operating Loss Carryforwards
Trading Symbol
Trading Symbol
Entity File Number
Entity File Number
Percentage of revenue contributed by related party
Percentage Of Revenue Contributed By Related Party
Percentage of revenue contributed by related party.
Research and development
Research and Development Expense
Purchase of short-term investments
Payments to Acquire Short-Term Investments
Laboratory equipment
Equipment [Member]
Achievement of First Patient Dosing Milestone
Achievement Of First Patient Dosing Milestone [Member]
Achievement of first patient dosing milestone.
Accrued research and development
Accrued Research And Development Expenses, Current
Accrued research and development expenses, current
Title of Individual
Title of Individual [Axis]
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense [Abstract]
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense [Abstract]
Other
Deferred Tax Assets, Tax Deferred Expense, Other
Number of shares granted during period (in shares)
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Accrued Expenses and Other Liabilities
Accrued Expenses And Other Liabilities [Member]
Accrued expenses and other liabilities.
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Amount available after tranche one
Debt Instrument, Amount Available After Tranche One
Debt Instrument, Amount Available After Tranche One
Other comprehensive loss:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Before January 1, 2018
Before January12018 [Member]
Before January 1,2018.
Accounts payable
Increase (Decrease) in Accounts Payable
Subsequent Events [Abstract]
Expected volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Income Taxes
Income Tax Disclosure [Text Block]
Revenue recognized from related party
Revenue from Related Parties
Supplemental disclosures of cash flow information:
Supplemental Cash Flow Disclosures [Abstract]
Supplemental Cash Flow Disclosures
Total intrinsic value of outstanding unvested restricted stock awards
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activities
Basic (USD per share)
Earnings Per Share, Basic
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Novartis
Novartis [Member]
Novartis.
Accounting Standards Update and Change in Accounting Principle [Table]
Accounting Standards Update and Change in Accounting Principle [Table]
Amount remaining for achievement
Collaboration And License Agreement Integrin Research Targets Amount, Remaining
Collaboration And License Agreement Integrin Research Targets Amount, Remaining
Counterparty Name
Counterparty Name [Domain]
Total stockholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Tax credits
Tax Credit Carryforward, Amount
Weighted- Average Exercise Price per Share, Forfeited (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Defined Contribution Plan, Plan Name [Extensible List]
Defined Contribution Plan, Plan Name [Extensible Enumeration]
Entity Interactive Data Current
Entity Interactive Data Current
Public and private offering, shares issued (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
2027
Long-Term Debt, Maturity, Year Five
Money Market Funds
Money Market Funds [Member]
Accumulated Deficit
Retained Earnings [Member]
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Common Stock
Common Stock [Member]
Percentage of payroll deductions
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Total other comprehensive loss
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Number of reportable segments
Number of Reportable Segments
Mature in 1 year or less
Mature In One Year Or Less [Member]
Mature in one year or less.
Thereafter
Long-Term Debt, Maturity, after Year Five
Income Taxes
Income Tax, Policy [Policy Text Block]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Statement [Table]
Statement [Table]
Weighted-Average Grant Date fair value, Vested (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Effective interest rate for the term loan
Debt Instrument, Interest Rate, Effective Percentage
Lease term extension period
Lessee, Operating Lease, Renewal Term
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions [Table Text Block]
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions
Current assets
Assets, Current [Abstract]
Unrecognized tax benefits, income tax penalties and interest expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Lease liabilities, non-current
Operating Lease, Liability, Noncurrent
Payment made under defined contribution plan
Defined Contribution Plan, Cost
Statistical Measurement
Statistical Measurement [Axis]
Average peer group volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions; Average Peer Group Volatility
Related Party Transaction
Related Party Transaction [Axis]
Leasehold improvements
Leasehold Improvements [Member]
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Equity Components
Equity Components [Axis]
Fair Value, Recurring
Fair Value, Recurring [Member]
Weighted- Average Exercise Price per Share, Exercisable (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Segments
Segment Reporting, Policy [Policy Text Block]
Document Fiscal Year Focus
Document Fiscal Year Focus
Additions for tax positions of prior year
Unrecognized Tax Benefits Increases Decreases Resulting From Prior Period Tax Positions
Amount of increase (decrease) in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Statement [Line Items]
Statement [Line Items]
Shares of common stock available for future issuance under the 2022 Inducement Plan
Two Thousand And Twenty Two Inducement Plan [Member]
Two Thousand And Twenty Two Inducement Plan
Other accrued liabilities
Accounts Payable and Other Accrued Liabilities, Current
Research and development credits
Deferred Tax Assets, in Process Research and Development
Outstanding and unvested, beginning balance (in shares)
Outstanding and unvested, ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Employee stock purchase plan, description
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Variable Rate [Domain]
Variable Rate [Domain]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
California
CALIFORNIA
Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Accumulated Other Comprehensive Loss
AOCI Attributable to Parent [Member]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Auditor Firm ID
Auditor Firm ID
Deferred tax liabilities:
Deferred Tax Liabilities, Gross [Abstract]
Document Transition Report
Document Transition Report
Local Phone Number
Local Phone Number
Summary of Option Activity Under the 2015 Plan and 2020 Plan
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Loss from operations
Operating Income (Loss)
Stock based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Other permanent differences
Effective Income Tax Rate Reconciliation, Tax Settlement, Other, Percent
Restricted Stock Awards
Restricted Stock Awards [Member]
Restricted stock awards.
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
State
State and Local Jurisdiction [Member]
Accrued expenses
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Accrued and other liabilities
Total accrued and other liabilities
Accrued Liabilities and Other Liabilities
Denominator
Weighted Average Number of Shares Outstanding Reconciliation [Abstract]
Receivable from related party transactions
Accounts Receivable, Related Parties
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Accrued expenses and other liabilities
Deferred Compensation Share-Based Arrangements, Liability, Current
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Number of income tax examinations pending
Income Tax Examination Number Of Examinations Pending
Income tax examination, number pending.
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Income tax provision
Income Tax Expense (Benefit)
Geographical
Geographical [Domain]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Valuation allowance
Valuation allowance at the beginning of the year
Valuation allowance at the end of the year
Deferred Tax Assets, Valuation Allowance
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Property and Equipment, Net
Property, Plant and Equipment, Policy [Policy Text Block]
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Income Statement [Abstract]
Income Statement [Abstract]
Options granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Entity Public Float
Entity Public Float
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Balance Sheet Location
Balance Sheet Location [Domain]
Document Fiscal Period Focus
Document Fiscal Period Focus
Intrinsic value of time-based stock options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Prepaid expenses
Deferred Tax Liabilities, Prepaid Expenses
Period of base rent abatement
Period Of Base Rent Abatement
Period Of Base Rent Abatement
Diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Expected volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Dividends paid (USD per share)
Common Stock, Dividends, Per Share, Cash Paid
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Number of Integrin research targets
Number Of Integrin Research Targets
Number of Integrin research targets.
Common stock, $0.0001 par value; 300,000,000 shares authorized at December 31, 2022 and 2021; and 48,941,254 and 36,083,301 shares issued and outstanding at December 31, 2022 and 2021, respectively;
Common Stock, Value, Issued
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Deferred tax assets:
Deferred Tax Assets, Gross [Abstract]
Weighted-Average Grant Date fair value, Issued (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Summary of Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Accounting Policies [Table]
Accounting Policies [Table]
Accounting policies.
Aggregate Intrinsic Value, Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Private Placement
Private Placement [Member]
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Term Loan Facility
Term Loan Facility [Member]
Term Loan Facility
Current liabilities
Liabilities, Current [Abstract]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Net loss attributable to common stockholders
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Leased premises under non cancelable operating lease
Leased Space Under Non Cancellable Operating Lease
Leased space under non cancellable operating lease.
Purchase of property and equipment in accounts payable and accrued liabilities
Capital Expenditures Incurred but Not yet Paid
Summary of Changes in Valuation Allowance for Deferred Tax Assets
Summary of Valuation Allowance [Table Text Block]
Income Statement Location
Income Statement Location [Domain]
Amendment Flag
Amendment Flag
Net cash (used in) provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Lease costs
Operating Lease, Cost
Term loan facility
Debt Instrument, Face Amount
Investment Type
Investment Type [Axis]
Short-Term Investments
Interest and other income
Investment, Policy [Policy Text Block]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Construction-in-progress
Construction in Progress [Member]
Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Impairment of long-lived assets
Impairment of Long-Lived Assets to be Disposed of
Entity Current Reporting Status
Entity Current Reporting Status
Summary of Net Operating Losses and Tax Credit Carryforwards
Schedule Of Net Operating Losses And Tax Credit Carryforwards Table [Table Text Block]
Tabular disclosure of net operating losses and tax credit carryforwards.
Accrued Liabilities and Other Liabilities [Abstract]
Accrued Liabilities and Other Liabilities [Abstract]
Other non-current assets
Other Assets, Noncurrent
Target level of achievement percentage
Share-Based Compensation Arrangement By Share-Based Payment Award, Target Level Of Achievement Percentage
Share-Based Compensation Arrangement By Share-Based Payment Award, Target Level Of Achievement Percentage
Number of Options, Exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Refundable security deposit
Security Deposit
Income tax computed at federal statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Lease term
Lessee, Operating Lease, Term of Contract
Counterparty Name
Counterparty Name [Axis]
Number of Options, Outstanding, Beginning balance (in shares)
Number of Options, Outstanding, Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Prepaid research and development
Prepaid Research And Development, Current
Prepaid Research And Development, Current
Earliest Tax Year
Earliest Tax Year [Member]
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
State taxes, net of federal tax benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Property and equipment, net
Total property and equipment, net
Property, Plant and Equipment, Net
Operating lease payments
Operating Lease, Payments
Latest Tax Year
Latest Tax Year [Member]
Outstanding stock option awards
Options to purchase common stock
Share-Based Payment Arrangement, Option [Member]
Other non-current assets
Increase (Decrease) in Other Noncurrent Assets
Title of Individual
Title of Individual [Domain]
Volatility
Expected stock price volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Performance-based restricted stock units
Performance-Based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units
Option exercises
Stock Issued During Period, Value, Stock Options Exercised
Long-term debt
Total
Long-Term Debt
Balance Sheet Location
Balance Sheet Location [Axis]
Debt Draw Period [Axis]
Debt Draw Period [Axis]
Debt Draw Period
Share price of shares issued (USD per share)
Sale of Stock, Price Per Share
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Total operating expenses
Operating Expenses
Starting from January 1, 2018
Starting From January12018 [Member]
Starting from January 1, 2018.
Maximum
Maximum [Member]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Common stock, voting rights
Number Of Votes Per Share Of Common Stock
Number Of Votes Per Share Of Common Stock
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Novartis Agreement RD For PLN-1474
Novartis Agreement RD For PLN-1474 [Member]
Novartis Agreement RD For PLN-1474
Repurchase Agreements and Similar Transactions, Maturity Periods
Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]
Total current assets
Assets, Current
Entity Small Business
Entity Small Business
General business credit—federal
Effective Income Tax Rate Reconciliation General Business Tax Credits Federal
Effective income tax rate reconciliation general business tax credits federal.
Measurement Frequency
Measurement Frequency [Domain]
Common Stock
Stockholders' Equity Note Disclosure [Text Block]
Noncash lease expense
Operating Lease, Right-of-Use Asset, Amortization Expense
Number of common stock issued (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Dividends declared (USD per share)
Common Stock, Dividends, Per Share, Declared
Revenue, remaining performance obligation, expected timing of satisfaction
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Property and Equipment, net
Property, Plant and Equipment Disclosure [Text Block]
Debt Draw, Tranche One
Debt Draw, Tranche One [Member]
Debt Draw, Tranche One
Aggregate Intrinsic Value, Outstanding balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Title of 12(b) Security
Title of 12(b) Security
Short-term investments
Short-Term Investments
Summary of Reconciliation of Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Non-employee Director
Nonemployee Director [Member]
Nonemployee Director.
Public Offering
Public Offering [Member]
Public Offering
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Class of Stock [Line Items]
Class of Stock [Line Items]
Public Offering And Private Placement
Public Offering And Private Placement [Member]
Public Offering And Private Placement
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
(Accretion) amortization on short-term investments
Accretion (Amortization) of Discounts and Premiums, Investments
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
U.S. Treasury securities included in cash and cash equivalents and short-term investments
US Treasury Securities [Member]
Defined Contribution Plan
Defined Contribution Plan [Text Block]
Weighted- Average Exercise Price per Share, Granted (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Adjusted Cost
Adjusted Cost
Debt Securities, Available-for-Sale, Amortized Cost
Shares used in computing net loss per share attributable to common stockholders:
Weighted-average common shares outstanding used to calculate net loss per share attributable to common stockholders:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Proceeds from the sale of shares
Sale of Stock, Consideration Received on Transaction
Repurchase Agreements and Similar Transactions, Maturity Periods
Repurchase Agreements and Similar Transactions, Maturity Periods [Domain]
Accounts payable
Accounts Payable, Current
Comprehensive loss:
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Income Tax Authority
Income Tax Authority [Axis]
Number of tranches
Debt Instrument, Number Of Tranches
Debt Instrument, Number Of Tranches
2026
Long-Term Debt, Maturity, Year Four
Summery of Remaining Contractual Maturities of Company’s Short-term Investments
Investments Classified by Contractual Maturity Date [Table Text Block]
Auditor Location
Auditor Location
Entity Filer Category
Entity Filer Category
Basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Share-based payment arrangement, expense
Share-Based Payment Arrangement, Expense
Share-Based Payment Arrangement, Expense
Commitments and contingencies
Commitments and Contingencies
Lease liability
Deferred Tax Assets, Lease Liability
Deferred Tax Assets, Lease Liability
Security Exchange Name
Security Exchange Name
Weighted- Average Exercise Price per Share, Outstanding, Beginning balance (USD per share)
Weighted- Average Exercise Price per Share, Outstanding, Ending balance (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Schedule of Shares Reserved for Future Issuance
Schedule Of Common Stock Reserved For Future Issuance Table [Table Text Block]
Schedule of common stock reserved for future issuance.
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Unvested restricted shares
Restricted Stock [Member]
Employee stock purchase plan offering period
Employee Stock Purchase Plan Offering Period
Employee stock purchase plan offering period.
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
General and administrative expenses
General and Administrative Expense [Member]
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Debt Draw, Tranche Three
Debt Draw, Tranche Three [Member]
Debt Draw, Tranche Three
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Shares of common stock available for future issuance under the 2020 Employee Stock Purchase Plan
Two Thousand And Twenty Employee Stock Purchase Plan [Member]
Two thousand and twenty employee stock purchase plan.
Options under plan may be granted for periods
Share Based Compensation Options Under Plan May Be Granted For Periods
Share based compensation options under plan may be granted for periods.
Total shares reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Cover [Abstract]
Cover [Abstract]
Schedule of Long-Term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
Leases and Rent Expense
Lessee, Leases [Policy Text Block]
Fair Value, Inputs, Level 3
Fair Value, Inputs, Level 3 [Member]
Computer equipment and software
Computer Equipment And Software [Member]
Computer equipment and software.
Entity Voluntary Filers
Entity Voluntary Filers
Lease term extension notice period
Lease Term Extension Notice Period
Lease term extension notice period.
Common stock shares outstanding percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Summary of Classification of Stock-based Compensation Expense
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Investments
Investments [Domain]
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Summary of Useful Lives of Property and Equipment
Property Plant And Equipment Useful Lives Table [Table Text Block]
Tabular disclosure of property plant and equipment useful lives.
Total liabilities and stockholders’ equity
Liabilities and Equity
Auditor Information [Abstract]
Auditor Information
Summary of Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Related Party
Related Party [Axis]
Long-Term Debt, Type [Axis]
Long-Term Debt, Type [Axis]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Total deferred tax assets
Deferred Tax Assets, Gross
Restricted stock awards
Restricted Common Stock Awards [Member]
Restricted common stock awards.
Level 2
Fair Value, Inputs, Level 2 [Member]
Tax credits Expiration year
Tax Credit Carryforwards Expiration Year
Tax credit carryforward expiration year.
Current Fiscal Year End Date
Current Fiscal Year End Date
Accrued and Other Liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Less: Present value discount
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Valuation Allowance [Abstract]
Valuation Allowance [Abstract]
Diluted (USD per share)
Earnings Per Share, Diluted
Net loss attributable to common stockholders
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Diluted
Sale of Stock
Sale of Stock [Domain]
Valuation allowance as a percentage on total deferred tax assets
Valuation Allowance As Percentage On Deferred Tax Assets
Valuation allowance as percentage on deferred tax assets.
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Payment of offering costs
Payments of Stock Issuance Costs
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Proceeds from upfront non-refundable license fee
Proceeds From Upfront Non Refundable License Fee
Proceeds from upfront non-refundable license fee.
Total current liabilities
Liabilities, Current
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Proceeds from issuances of common stock under benefit plans
Proceeds From Issuances Of Common Stock Under Benefit Plans
Proceeds From Issuances Of Common Stock Under Benefit Plans
January 1
December 31
Unrecognized Tax Benefits
Net deferred taxes
Deferred Tax Assets, Net of Valuation Allowance
Performance-Based Restricted Stock Units, Clinical Development Milestones
Performance-Based Restricted Stock Units, Clinical Development Milestones [Member]
Performance-Based Restricted Stock Units, Clinical Development Milestones
Summary of Restricted Stock Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Pre-tax U.S. book loss
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Revenue, remaining performance obligation, amount
Revenue, Remaining Performance Obligation, Amount
Expiration period from date of grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Due from related parties
Due from Related Parties
Corporate debt securities included in cash and cash equivalents and short-term investments
Corporate Debt Securities [Member]
Common stock fair market value percentage
Common Stock Fair Market Value Percentage
Common stock fair market value percentage .
Risk-free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Fixed asset basis
Deferred Tax Liabilities, Fixed Asset Basis
Deferred Tax Liabilities, Fixed Asset Basis
Schedule of Operating Lease Liability
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Entity Address, Address Line One
Entity Address, Address Line One
Income Tax Authority
Income Tax Authority [Domain]
Contract liabilities
Contract with Customer, Liability
Exercise price as a percentage of estimated grant date fair value of shares
Share Based Compensation Arrangement By Share Based Payment Award Exercise Price With Purchase Price Of Common Stock Percentage Of Estimated Grant Date Fair Value For Shareholders
Share based compensation arrangement by share based payment award exercise price with purchase price of common stock percentage of estimated grant date fair value for shareholders.
Net unrealized loss on short-term investments
Unrealized Gain (Loss) on Investments
Product and Service
Product and Service [Axis]
Increases recorded to income tax provision
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Interest expense
Interest Expense
Net unrealized loss on short-term investments
Net unrealized loss on short-term investments
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
U.S. government agency securities included in short-term investments
US Government Corporations and Agencies Securities [Member]
Transaction price of Novartis agreement
Related Party Transaction, Amounts of Transaction
Schedule of Accrued Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Equity [Abstract]
Equity [Abstract]
Debt Draw Period [Domain]
Debt Draw Period [Domain]
Debt Draw Period [Domain]
Right of use asset
Deferred Tax Liabilities, Leasing Arrangements
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Entity Tax Identification Number
Entity Tax Identification Number
Less: unamortized debt issuance costs
Unamortized Debt Issuance Expense
Other Non-current Assets
Other Noncurrent Assets [Member]
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Text Block]
Prepaid Expenses And Other Current Assets
Summary of Reconciliation of U.S. Federal Statutory Income Tax Rate to Company’s Effective Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Net (decrease) increase in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Cash, Cash Equivalents, and Short-term Investments [Abstract]
Cash, Cash Equivalents, and Short-Term Investments [Abstract]
Entity Central Index Key
Entity Central Index Key
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Measurement Frequency
Measurement Frequency [Axis]
Research and Development Expenses
Research and Development Expense, Policy [Policy Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Novartis Collaboration and License Agreement (the "Novartis Agreement")
Collaborative Arrangement Disclosure [Text Block]
Concentration of Credit Risk and Other Risks and Uncertainties Policy
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Tax Period
Tax Period [Axis]
Loan Agreement
Loan Agreement [Member]
Loan Agreement
City Area Code
City Area Code
General and administrative
General and Administrative Expense
Assets
Assets [Abstract]
Long-Term Debt, Type [Domain]
Long-Term Debt, Type [Domain]
Retirement Benefits [Abstract]
Retirement Benefits [Abstract]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Sale of Stock [Axis]
Sale of Stock [Axis]
Other
Other Prepaid Expense, Current
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Annual percentage increase to base rent
Operating Lease, Annual Increase To Base Rent, Percent
Operating Lease, Annual Increase To Base Rent, Percent
Proceeds from sale of common stock in a public offering
Proceeds from Issuance Initial Public Offering
Liabilities measured at fair value
Financial Liabilities Fair Value Disclosure
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
2023
Long-Term Debt, Maturity, Year One
Supplemental disclosures of noncash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Contractual arrangements cancellation period
Contractual Arrangements Cancellation Period
Contractual arrangements cancellation period.
Grant date fair value of stock option (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Variable Rate [Axis]
Variable Rate [Axis]
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Research and Development
Research and development expenses
Research and Development Expense [Member]
Capitalized research and development
Deferred Tax Assets, Capitalized Research And Development
Deferred Tax Assets, Capitalized Research And Development
Debt instrument remaining maturity period at date of purchase
Debt Instrument Remaining Maturity Period At Date Of Purchase
Debt instrument remaining maturity period at date of purchase.
Reconciliation of Numerator and Denominator Used in Calculation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Interest expense
Interest And Other Income, Net
Interest And Other Income, Net
Net operating losses, Expiration year
Operating Loss Carryforwards Expiration Year
Year that operating loss carryforwards expire.
Right-of-use assets obtained in exchange for new operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Organization and Description of Business
Business Description and Basis of Presentation [Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Schedule Of Prepaid Expenses And Other Current Assets [Table Text Block]
Schedule Of Prepaid Expenses And Other Current Assets
Retirement Plan Name, Other [Member]