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  <xs:element id="plrx_TermLoanFacilityMember" abstract="true" name="TermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_AccruedResearchAndDevelopmentExpensesCurrent" abstract="false" name="AccruedResearchAndDevelopmentExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_UCRegentsMember" abstract="true" name="UCRegentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_UnderlyingCommonStockFairValue" abstract="false" name="UnderlyingCommonStockFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="plrx_DebtInstrumentTrancheOneAmountUndrawn" abstract="false" name="DebtInstrumentTrancheOneAmountUndrawn" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_DebtDrawTrancheTwoMember" abstract="true" name="DebtDrawTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_LicenseAgreementsTextBlock" abstract="false" name="LicenseAgreementsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="plrx_DebtInstrumentNumberOfTranches" abstract="false" name="DebtInstrumentNumberOfTranches" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="plrx_NovartisAgreementRDForIntegrinResearchTargetsMember" abstract="true" name="NovartisAgreementRDForIntegrinResearchTargetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_PerformanceBasedRestrictedStockUnitsMember" abstract="true" name="PerformanceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_ThirdRockVenturesMember" abstract="true" name="ThirdRockVenturesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_LeaseTermExtensionNoticePeriod" abstract="false" name="LeaseTermExtensionNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="plrx_NumberOfIntegrinResearchTargets" abstract="false" name="NumberOfIntegrinResearchTargets" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="plrx_PrepaidResearchAndDevelopmentCurrent" abstract="false" name="PrepaidResearchAndDevelopmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_ScheduleOfCommonStockReservedForFutureIssuanceTableTableTextBlock" abstract="false" name="ScheduleOfCommonStockReservedForFutureIssuanceTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="plrx_AchievementOfFirstPatientDosingMilestoneMember" abstract="true" name="AchievementOfFirstPatientDosingMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_InterestAndOtherIncomeNet" abstract="false" name="InterestAndOtherIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_ShareBasedCompensationOptionsUnderPlanMayBeGrantedForPeriods" abstract="false" name="ShareBasedCompensationOptionsUnderPlanMayBeGrantedForPeriods" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="plrx_ScheduleOfPrepaidExpensesAndOtherCurrentAssetsTableTextBlock" abstract="false" name="ScheduleOfPrepaidExpensesAndOtherCurrentAssetsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="plrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAveragePeerGroupCorrelationCoefficient" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAveragePeerGroupCorrelationCoefficient" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="plrx_ProceedsFromUpfrontNonRefundableLicenseFee" abstract="false" name="ProceedsFromUpfrontNonRefundableLicenseFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_UnderwritersMember" abstract="true" name="UnderwritersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_LicenseAgreementsLineItems" abstract="true" name="LicenseAgreementsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="plrx_MilestoneAndAnnualRoyaltyPaid" abstract="false" name="MilestoneAndAnnualRoyaltyPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_IncentiveStockOptionsAndNonqualifiedStockOptionsMember" abstract="true" name="IncentiveStockOptionsAndNonqualifiedStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="plrx_DeferredOfferingCostsInAccountsPayableAndAccruedLiabilities" abstract="false" name="DeferredOfferingCostsInAccountsPayableAndAccruedLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="plrx_EmployeeStockPurchasePlanOfferingPeriod" abstract="false" name="EmployeeStockPurchasePlanOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
