Dividends paid (USD per share)
Common Stock, Dividends, Per Share, Cash Paid
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Accrued expenses
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Statistical Measurement
Statistical Measurement [Domain]
Short-Term Investments
Interest and other income (expense)
Investment, Policy [Policy Text Block]
Adjusted Cost
Debt Securities, Available-for-Sale, Amortized Cost, Excluding Accrued Interest, before Allowance for Credit Loss
Total property and equipment held for sale, net
Disposal Group, Including Discontinued Operation, Property, Plant and Equipment
Award Timing Predetermined
Award Timing Predetermined [Flag]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Tax Expense (Benefit), Share-Based Payment Arrangement, Percent
Entity File Number
Entity File Number
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Debt Draw, Tranche Two
Debt Draw, Tranche Two [Member]
Debt Draw, Tranche Two
Released (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Releases in Period
Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Releases in Period
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Tabular List, Table
Tabular List [Table Text Block]
Leases [Abstract]
Leases [Abstract]
2020 Stock Options and Incentive Plan and 2022 Inducement Plan
Two Thousand And Twenty Stock Options And Incentive Plan And Two Thousand Twenty Two Inducement Plan [Member]
Two Thousand And Twenty Stock Options And Incentive Plan And Two Thousand Twenty Two Inducement Plan
Recently Adopted Accounting Pronouncements and Accounting Pronouncements Not Yet Adopted
New Accounting Pronouncements, Policy [Policy Text Block]
Purchase of short-term investments
Payments to Acquire Short-Term Investments
Accounts payable
Increase (Decrease) in Accounts Payable
Type of Restructuring [Domain]
Type of Restructuring [Domain]
R&D Credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Performance-Based Restricted Stock Units, TSR Goal
Performance-Based Restricted Stock Units, TSR Goal [Member]
Performance-Based Restricted Stock Units, TSR Goal
Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Net loss per share - basic (USD per share)
Earnings Per Share, Basic
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Warrant, Acquiring Person's beneficial ownership threshold, non-passive investor
Class Of Warrant Or Right, Acquiring Person's Beneficial Ownership Threshold, Non-Passive Investor
Class Of Warrant Or Right, Acquiring Person's Beneficial Ownership Threshold, Non-Passive Investor
Total shares reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Interest and other income (expense), net
Interest and other (income) expense, net
Interest and Other Income (Expense), Net
Interest and Other Income (Expense), Net
Stock based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Worldwide changes in unrecognized tax benefits
Effective Income Tax Rate Reconciliation, Tax Contingency, Percent
Total deferred tax assets
Deferred Tax Assets, Gross
Stock, Class of Stock [Table]
Stock, Class of Stock [Table]
Schedule of Segment Reporting Expenses
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Shares of common stock available for future grants under the 2020 Stock Option and Incentive Plan
Two Thousand And Twenty Stock Options And Incentive Plan [Member]
2020 Stock options and incentive plan.
Prepaid licenses
Prepaid Licenses, Current
Prepaid Licenses, Current
Accrued Liabilities and Other Liabilities [Abstract]
Accrued Liabilities and Other Liabilities [Abstract]
Schedule of Cash and Cash Equivalents, Money Market Funds and Short-term Investments by Significant Investment Category
Cash, Cash Equivalent, and Investment [Table Text Block]
Underlying common stock fair value (USD per share)
Underlying Common Stock Fair Value
Underlying common stock fair value.
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Outstanding stock options
Options to purchase common stock
Share-Based Payment Arrangement, Option [Member]
U.S. Government Agency Securities
US Government Corporations and Agencies Securities [Member]
Accounting Policies [Line Items]
Accounting Policies [Line Items]
Accounting policies.
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Research and Development Expenses
Research and Development Expense, Policy [Policy Text Block]
Percentage
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Antidilutive Securities
Antidilutive Securities [Axis]
Incentive Stock Options and Nonqualified Stock Options
Incentive Stock Options And Nonqualified Stock Options [Member]
Incentive stock options and nonqualified stock options.
Total stockholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Measurement Frequency
Measurement Frequency [Axis]
Insider Trading Policies and Procedures [Line Items]
Stock options and ESPP
Employee Stock Option And Purchase Plan [Member]
Employee stock option and purchase plan.
Share-based payment arrangement, expense
Total stock-based compensation expense
Share-Based Payment Arrangement, Expense
Schedule of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Tax Period
Tax Period [Domain]
Issuance of common stock under benefit plans (in shares)
Stock Issued During Period, Shares, Employee Benefit Plan
Current assets
Assets, Current [Abstract]
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Total liabilities and stockholders’ equity
Liabilities and Equity
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Fair Value, Recurring
Fair Value, Recurring [Member]
Number of Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Concentration of Credit Risk and Other Risks and Uncertainties
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
State
State and Local Jurisdiction [Member]
Cover [Abstract]
Cover [Abstract]
Maximum
Maximum [Member]
Adjusted Cost
Debt Securities, Held-to-Maturity, Excluding Accrued Interest, before Allowance for Credit Loss
General and administrative expenses
General and Administrative Expense [Member]
Weighted- average exercise price per share, exercisable (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Schedule of Operating Lease Liability
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Novartis Agreement
Novartis Agreement [Member]
Novartis agreement.
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Pay vs Performance Disclosure [Line Items]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Total discounted lease payments
Operating Lease, Liability
Retirement Benefits [Abstract]
Retirement Benefits [Abstract]
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Line of Credit Facility, Lender [Domain]
Line of Credit Facility, Lender [Domain]
Schedule of Changes in Valuation Allowance for Deferred Tax Assets
Summary of Valuation Allowance [Table Text Block]
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Liabilities measured at fair value
Financial Liabilities Fair Value Disclosure
Entity Shell Company
Entity Shell Company
Effective interest rate for the term loan
Long-Term Debt, Weighted Average Interest Rate, over Time
Schedule of Weighted-average Remaining Lease Terms and Discount Rates
Assets And Liabilities, Lessee [Table Text Block]
Assets And Liabilities, Lessee
Schedule of Long-Term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
Proceeds from sale of property, plant and equipment
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from term loan, net of issuance costs
Proceeds from Issuance of Debt
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Common Stock, par value $0.0001 per share
Common Stock, Par Value $0.0001 Per Share [Member]
Common Stock, Par Value $0.0001 Per Share
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Company Selected Measure Amount
Company Selected Measure Amount
2028
Lessee, Operating Lease, Liability, to be Paid, Year Three
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Name
Measure Name
Letter of Credit
Letter of Credit [Member]
Pre-tax U.S. book loss
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Lease liabilities, current
Total current operating lease liabilities
Operating Lease, Liability, Current
Nondeductible Items:
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Property and equipment held for sale (Note 4)
Disposal Group, Including Discontinued Operation, Property, Plant and Equipment, Current
Class of Stock [Line Items]
Class of Stock [Line Items]
Number of shares per right entitled to purchase (in shares)
Number Of Shares Per Right Entitled To Purchase
Number Of Shares Per Right Entitled To Purchase
Document Fiscal Period Focus
Document Fiscal Period Focus
Award Timing Method
Award Timing Method [Text Block]
Furniture and Fixture
Furniture and Fixtures [Member]
Award Type
Award Type [Axis]
Number of classes of stock authorized
Number Of Classes Of Stock Authorized
Number Of Classes Of Stock Authorized
Long-term debt (Note 7)
Long-Term Debt
Total assets
Assets
Employee-related expenses - research and development (excluding stock-based compensation)
Research And Development Expense, Adjusted
Research And Development Expense, Adjusted
Valuation Allowance [Abstract]
Valuation Allowance [Abstract]
Released (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Released, Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Released, Weighted Average Grant Date Fair Value
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Trading Symbol
Trading Symbol
2029
Lessee, Operating Lease, Liability, to be Paid, Year Four
Cash and Cash Equivalents, Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Geographical
Geographical [Domain]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Income Taxes
Income Tax, Policy [Policy Text Block]
Entity Address, City or Town
Entity Address, City or Town
Cash flows from operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
R&D Credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Other segment items
Segment Reporting, Other Segment Item, Amount
Supplemental disclosures of cash flow information related to leases:
Additional Cash Flow Elements and Supplemental Cash Flow Information [Abstract]
Net deferred taxes
Deferred Tax Assets, Net of Valuation Allowance
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Statement of Income Location, Balance
Statement of Income Location, Balance [Domain]
Vesting of RSUs
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Reconciliation of cash, cash equivalents, and restricted cash reported in the balance sheets
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation [Abstract]
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Dividends declared (USD per share)
Common Stock, Dividends, Per Share, Declared
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Right-of-use assets obtained in exchange for new operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Outstanding, beginning balance (in shares)
Outstanding, ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
2015 Equity and 2020 Incentive Plan
Two Thousand Fifteen And Two Thousand Twenty Equity Incentive Plan [Member]
Two thousand fifteen and two thousand twenty equity incentive plan .
Level 2
Fair Value, Inputs, Level 2 [Member]
Document Financial Statement Error Correction
Document Financial Statement Error Correction [Flag]
State taxes, net of federal tax benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Operating Leases
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Plan Name
Plan Name [Axis]
Property and Equipment, Net
Property, Plant and Equipment, Policy [Policy Text Block]
Document Information [Table]
Document Information [Table]
PEO
PEO [Member]
Employee Severance
Employee Severance [Member]
Schedule of Remaining Contractual Maturities of Company’s Short-term Investments
Investments Classified by Contractual Maturity Date [Table Text Block]
Increases recorded to income tax provision
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Number of common stock issued (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Change in Valuation Allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Accumulated Deficit
Retained Earnings [Member]
Prepaid expenses and other current assets (Note 5)
Total prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Income Tax Jurisdiction
Income Tax Jurisdiction [Axis]
Restricted Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Schedule of Accrued Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Restatement Determination Date
Restatement Determination Date
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Total cash, cash equivalents, and restricted cash shown in the statements of cash flows
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Income Statement [Abstract]
Income Statement [Abstract]
Income tax provision
Income tax provision
Income Tax Expense (Benefit)
Warrant, exercisable after beneficial ownership threshold announcement, number of days
Class Of Warrant Or Right, Exercisable After Beneficial Ownership Threshold Announcement, Number Of Days
Class Of Warrant Or Right, Exercisable After Beneficial Ownership Threshold Announcement, Number Of Days
Loan agreement interest rate
Debt Instrument, Basis Spread on Variable Rate
Fair Value Measurements, Non-recurring Basis
Fair Value, Nonrecurring [Member]
Document Information [Line Items]
Document Information [Line Items]
Preferred stock, shares issued
Preferred Stock, Shares Issued
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Mature in 1 to 2 years
Mature In One To Two Years [Member]
Mature in one to two years.
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Total property and equipment, gross
Property, Plant and Equipment, Gross
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Restructuring of Operations
Restructuring and Related Activities Disclosure [Text Block]
Non-cash operating lease expense
Operating Lease, Right-of-Use Asset, Periodic Reduction
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
City Area Code
City Area Code
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
All Trading Arrangements
All Trading Arrangements [Member]
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Weighted- average remaining contractual term (in years), vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Accrued liabilities (Note 6)
Total accrued liabilities
Accrued Liabilities, Current
Deferred tax liabilities:
Deferred Tax Liabilities, Gross [Abstract]
Outstanding and unvested, beginning balance (in shares)
Outstanding and unvested, ending balance (in shares)
Outstanding and unvested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
Cash flows from investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
General and administrative
General and Administrative Expense
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Market Value
Debt Securities, Available-for-Sale, Excluding Accrued Interest
Property, plant and equipment, useful life
Property, Plant and Equipment, Useful Life
Preferred stock, par value (USD per share)
Preferred Stock, Par or Stated Value Per Share
Subsequent Event
Subsequent Event [Member]
Schedule of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for Stock Option Awards
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Total expense
Lease, Cost
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
Schedule of Operating and Variable Lease Cost
Lease, Cost [Table Text Block]
PEO Total Compensation Amount
PEO Total Compensation Amount
Long-Term Debt, Type [Axis]
Long-Term Debt, Type [Axis]
Depreciation expense
Depreciation
Weighted- average exercise price per share, vested and expected to vest (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Money Market Funds
Money Market Funds [Member]
Repurchase Agreements and Similar Transactions, Maturity Periods
Repurchase Agreements and Similar Transactions, Maturity Periods [Axis]
Equity Components
Equity Components [Axis]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Unrecognized Tax Benefits [Roll Forward]
Unrecognized Tax Benefits [Roll Forward]
Auditor Name
Auditor Name
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Laboratory equipment
Equipment [Member]
Number of reportable segments
Number of Reportable Segments
Accrued research and development
Accrued Research And Development Expenses, Current
Accrued research and development expenses, current
Restructuring Cost and Reserve [Line Items]
Restructuring Cost and Reserve [Line Items]
Other Performance Measure, Amount
Other Performance Measure, Amount
Weighted- Average Exercise Price per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Total current liabilities
Liabilities, Current
Amount
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Reduction in workforce, percent
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Before January 1, 2018
Before January12018 [Member]
Before January 1,2018.
Forfeited (in shares)
Shares Issued, Shares, Share-Based Payment Arrangement, Forfeited
Individual:
Individual [Axis]
Payment made under defined contribution plan
Defined Contribution Plan, Cost
Restricted cash
Restricted Cash
Income Tax Jurisdiction
Income Tax Jurisdiction [Domain]
Document Annual Report
Document Annual Report
Research and development expenses
Research and Development
Research and Development Expense [Member]
Additional paid-in capital
Additional Paid in Capital, Common Stock
Supplemental disclosures of cash flow information:
Supplemental Cash Flow Disclosures [Abstract]
Supplemental Cash Flow Disclosures
Net cash provided by investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activity
Document Fiscal Year Focus
Document Fiscal Year Focus
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Lender Name [Axis]
Lender Name [Axis]
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Research and development credits
Deferred Tax Asset, In-Process Research and Development
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Entity Interactive Data Current
Entity Interactive Data Current
Operating lease costs
Operating Lease, Cost
(Reductions) additions for tax positions of prior year
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Plan Name
Plan Name [Domain]
Unrecognized compensation expense, weighted average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Valuation allowance
Valuation allowance at the beginning of the year
Valuation allowance at the end of the year
Deferred Tax Assets, Valuation Allowance
Equity [Abstract]
Equity [Abstract]
Aggregate intrinsic value, exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Stock Based Compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Segment
Segment Reporting Disclosure [Text Block]
U.S. Treasury securities
US Treasury Securities [Member]
Net operating losses
Deferred Tax Assets, Operating Loss Carryforwards
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Landlord
Landlord [Member]
Landlord
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Leases
Lessee, Leases [Policy Text Block]
Mature in 1 year or less
Mature In One Year Or Less [Member]
Mature in one year or less.
Other non-current assets
Other Assets, Noncurrent
Entity Central Index Key
Entity Central Index Key
PEO Name
PEO Name
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Comprehensive loss:
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Arrangement Duration
Trading Arrangement Duration
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Expected volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Financial Instruments
Financial Instruments Disclosure [Text Block]
Nondeductible Items:
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Segments [Axis]
Segments [Axis]
Exercise price (USD per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Exercise Price
Award Exercise Price
Entity Filer Category
Entity Filer Category
Local Phone Number
Local Phone Number
Class of Stock [Domain]
Class of Stock [Domain]
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Income tax computed at federal statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Assets
Assets [Abstract]
Credit Facility [Axis]
Credit Facility [Axis]
Maturity of short-term investments
Proceeds from Maturities, Prepayments and Calls of Short-Term Investments
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Shares of common stock available for future issuance under the 2022 Inducement Plan
Two Thousand And Twenty Two Inducement Plan [Member]
Two Thousand And Twenty Two Inducement Plan
Debt Instrument [Axis]
Debt Instrument [Axis]
Forfeited (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Loss on extinguishment of debt (Note 7)
Loss on extinguishment of debt
Loss on extinguishment of debt
Gain (Loss) on Extinguishment of Debt
Credit Facility [Domain]
Credit Facility [Domain]
Stockholders’ equity
Equity, Attributable to Parent [Abstract]
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Amount subject to lender's discretion
Line Of Credit, Amount Subject To Lender's Discretion
Line Of Credit, Amount Subject To Lender's Discretion
Vesting rights, percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Entity Address, Address Line One
Entity Address, Address Line One
Research and development
Research and Development Expense
Accumulated Other Comprehensive (Loss) Gain
AOCI Attributable to Parent [Member]
Interest rate, stated percentage
Debt Instrument, Interest Rate, Stated Percentage
Lease liabilities, non-current
Total non-current operating lease liabilities
Operating Lease, Liability, Noncurrent
Entity Voluntary Filers
Entity Voluntary Filers
Reconciliation of segment loss
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Abstract]
Fair Value as of Grant Date
Award Grant Date Fair Value
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Entity Registrant Name
Entity Registrant Name
Other non-current assets
Increase (Decrease) in Other Noncurrent Assets
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Net operating losses
Operating Loss Carryforwards
Section 162(m)
Effective Income Tax Rate Reconciliation, Nondeductible, Executive Compensation Section, 162(m) Limitation
Effective Income Tax Rate Reconciliation, Nondeductible, Executive Compensation Section, 162(m) Limitation
Worldwide changes in unrecognized tax benefits
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Line of credit facility, conditional borrowing capacity
Line Of Credit Facility, Conditional Borrowing Capacity
Line Of Credit Facility, Conditional Borrowing Capacity
Number of income tax examinations pending
Income Tax Examination Number Of Examinations Pending
Income tax examination, number pending.
Assets measured at fair value
Assets, Fair Value Disclosure
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Interest receivable
Interest Receivable, Current
Counterparty Name
Counterparty Name [Domain]
2027
Lessee, Operating Lease, Liability, to be Paid, Year Two
Number of operating segments
Number of Operating Segments
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Weighted- average remaining contractual term (in years), outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Rights Agreement
Rights Agreement [Member]
Rights Agreement
Granted (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Title
Trading Arrangement, Individual Title
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Tax Credit:
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Temporary Equity Disclosure [Abstract]
Temporary Equity Disclosure [Abstract]
Restatement Determination Date:
Restatement Determination Date [Axis]
Impairment loss recognized
Impairment of Long-Lived Assets to be Disposed of
Non-PEO NEO
Non-PEO NEO [Member]
Aggregate intrinsic value, outstanding balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Right of use asset
Deferred Tax Liabilities, Leasing Arrangements
Drug discovery platform, proprietary library, number of integrin binding molecules (over)
Drug Discovery Platform, Proprietary Library, Number Of Integrin Binding Molecules
Drug Discovery Platform, Proprietary Library, Number Of Integrin Binding Molecules
Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Name
Trading Arrangement, Individual Name
Award Type
Award Type [Domain]
2026
Lessee, Operating Lease, Liability, to be Paid, Year One
Equity Awards Adjustments
Equity Awards Adjustments [Member]
Leasehold improvements
Leasehold Improvements [Member]
Bexotegrast - clinical trial and outside service third party contracting costs
Clinical Trial And Outside Service Third Party Contracting Costs
Clinical Trial And Outside Service Third Party Contracting Costs
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Compensation Amount
Outstanding Recovery Compensation Amount
Term loan facility
Debt Instrument, Face Amount
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Expected dividends
Expected dividend
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Accounting Policies [Table]
Accounting Policies [Table]
Accounting policies.
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Payments for restructuring
Payments for Restructuring
Unvested and outstanding, beginning balance (USD per share)
Unvested and outstanding, ending balance (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Restricted cash
Restricted Cash, Noncurrent
Restructuring Type [Axis]
Restructuring Type [Axis]
Deferred Tax Assets, Valuation Allowance [Roll Forward]
Deferred Tax Assets, Valuation Allowance [Roll Forward]
Deferred Tax Assets, Valuation Allowance
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Term Loan Facility
Term Loan Facility [Member]
Term Loan Facility
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Cash and cash equivalents
Cash Equivalents, at Carrying Value
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Leased premises under non cancelable operating lease
Leased Space Under Non Cancellable Operating Lease
Leased space under non cancellable operating lease.
Tax Credit:
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Accumulated other comprehensive (loss) gain
Accumulated Other Comprehensive Income (Loss), Net of Tax
Section 162(m)
Effective Income Tax Rate Reconciliation, Nondeductible, Executive Compensation Section, 162(m) Limitation, Amount
Effective Income Tax Rate Reconciliation, Nondeductible, Executive Compensation Section, 162(m) Limitation, Amount
Aggregate intrinsic value, vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Financial Instruments [Domain]
Financial Instruments [Domain]
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Auditor Firm ID
Auditor Firm ID
Segments [Domain]
Segments [Domain]
Statement of Income Location, Balance
Statement of Income Location, Balance [Axis]
Line of credit facility, remaining borrowing capacity
Line of Credit Facility, Remaining Borrowing Capacity
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Repurchase Agreements and Similar Transactions, Maturity Periods
Repurchase Agreements and Similar Transactions, Maturity Periods [Domain]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Permanent Items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Minimum
Minimum [Member]
Schedule of Net Operating Losses and Tax Credit Carryforwards
Schedule Of Net Operating Losses And Tax Credit Carryforwards Table [Table Text Block]
Tabular disclosure of net operating losses and tax credit carryforwards.
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Company Selected Measure Name
Company Selected Measure Name
Debt
Debt Disclosure [Text Block]
Preferred stock, $0.0001 par value 10,000,000 shares authorized at December 31, 2025 and 2024, none issued or outstanding at December 31, 2025 and 2024
Preferred Stock, Value, Issued
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Accounts payable
Accounts Payable, Current
Cash paid for operating lease liabilities in operating cash flows
Operating Lease, Payments
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
All Executive Categories
All Executive Categories [Member]
Schedule of Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Common stock, $0.0001 par value; 300,000,000 shares authorized at December 31, 2025 and 2024; and 61,449,290 and 60,860,838 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively;
Common Stock, Value, Issued
Tax Period
Tax Period [Axis]
Expected volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Short-term investments
Short-Term Investments
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Prepaid research and development
Prepaid Research And Development, Current
Prepaid Research And Development, Current
Weighted average shares used in computing net loss per share - diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Segment
Segment Reporting, Policy [Policy Text Block]
Commitments and Contingencies (Note 14)
Commitments and Contingencies
No Trading Symbol Flag
No Trading Symbol Flag
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Series A Junior Participating Preferred Purchase Rights
Series A Junior Participating Preferred Purchase Rights [Member]
Series A Junior Participating Preferred Purchase Rights
Other
Other Prepaid Expense, Current
Entity Small Business
Entity Small Business
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Unrecognized tax benefits, income tax penalties and interest expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Document Transition Report
Document Transition Report
Performance-based restricted stock units
Performance-Based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units
Short-term investments
Short-Term Investments [Member]
Underlying Securities
Award Underlying Securities Amount
Debt Draw Period [Axis]
Debt Draw Period [Axis]
Debt Draw Period
Equity Component
Equity Component [Domain]
Document Period End Date
Document Period End Date
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Starting from January 1, 2018
Starting From January12018 [Member]
Starting from January 1, 2018.
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Income Taxes
Income Tax Disclosure [Text Block]
Line of credit facility, current borrowing capacity
Proceeds from Lines of Credit
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Weighted- average remaining contractual term (in years), exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Schedule of Reconciliation of Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
General business credit—federal
Effective Income Tax Rate Reconciliation General Business Tax Credits Federal
Effective income tax rate reconciliation general business tax credits federal.
Defined Contribution Plan
Defined Contribution Plan [Text Block]
Document Type
Document Type
Fair Value, Inputs, Level 3
Fair Value, Inputs, Level 3 [Member]
Net Loss Per Share Attributable to Common Stockholders
Earnings Per Share [Text Block]
Name
Outstanding Recovery, Individual Name
Other accrued liabilities
Accounts Payable and Other Accrued Liabilities, Current
California
CALIFORNIA
Other variable costs
Variable Lease, Cost
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
All Individuals
All Individuals [Member]
Long-Term Debt, Type [Domain]
Long-Term Debt, Type [Domain]
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Warrant, Acquiring Person's beneficial ownership threshold, passive investor
Class Of Warrant Or Right, Acquiring Person's Beneficial Ownership Threshold, Passive Investor
Class Of Warrant Or Right, Acquiring Person's Beneficial Ownership Threshold, Passive Investor
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Number of options, vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Name
Forgone Recovery, Individual Name
Expiration period from date of grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Total current assets
Assets, Current
Statistical Measurement
Statistical Measurement [Axis]
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Restricted cash
Restricted Cash Equivalent
Common stock shares outstanding percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Common stock, voting rights
Number Of Votes Per Each Share Of Common Stock
Number Of Votes Per Each Share Of Common Stock
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Intrinsic value of time-based stock options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Issuance of common stock under benefit plans
Stock Issued During Period, Value, Employee Benefit Plan
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense [Abstract]
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense [Abstract]
Customer payment term duration
Customer Payment Term Duration
Customer Payment Term Duration
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Amount undrawn
Debt Instrument, Amount Undrawn
Debt Instrument, Amount Undrawn
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Total other comprehensive loss
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Current liabilities
Liabilities, Current [Abstract]
Weighted- Average Remaining Contractual Term (in Years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Geographical
Geographical [Axis]
Lessee, Lease, Description [Line Items]
Lessee, Lease, Description [Line Items]
Total operating expenses
Operating Expenses
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Line of credit
Long-Term Line of Credit
Level 1
Fair Value, Inputs, Level 1 [Member]
Accrued liabilities
Increase (Decrease) in Accrued Liabilities
Net loss per share - diluted (USD per share)
Earnings Per Share, Diluted
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Title of 12(b) Security
Title of 12(b) Security
Lessee, Lease, Description [Table]
Lessee, Lease, Description [Table]
Supplemental disclosures of noncash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Prepaid insurance
Prepaid Insurance
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
Organization and Description of Business
Business Description and Basis of Presentation [Text Block]
Auditor Location
Auditor Location
Thereafter
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Tax credits
Tax Credit Carryforward, Amount
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Federal
Domestic Tax Jurisdiction [Member]
Accrued Liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Lease liability
Deferred Tax Assets, Lease Liability
Deferred Tax Assets, Lease Liability
Less: Present value discount
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Schedule of Shares Reserved for Future Issuance
Schedule Of Common Stock Reserved For Future Issuance Table [Table Text Block]
Schedule of common stock reserved for future issuance.
Permanent Items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Income taxes paid
Income Taxes Paid, Net
Employee stock purchase plan offering period
Employee Stock Purchase Plan Offering Period
Employee stock purchase plan offering period.
Exercised (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Cash equivalents
Cash Equivalents [Member]
Award Timing Disclosures [Line Items]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Shares of common stock available for future issuance under the 2020 ESPP
2020 Employee Stock Purchase Plan
Two Thousand And Twenty Employee Stock Purchase Plan [Member]
Two thousand and twenty employee stock purchase plan.
Options under plan may be granted for periods
Share Based Compensation Options Under Plan May Be Granted For Periods
Share based compensation options under plan may be granted for periods.
Granted (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Accrued compensation and benefits
Employee-related Liabilities, Current
Measurement Frequency
Measurement Frequency [Domain]
Property and Equipment, net
Property, Plant and Equipment Disclosure [Text Block]
Total undiscounted lease payments
Total undiscounted lease payments
Lessee, Operating Lease, Liability, to be Paid
Lease term extension period
Lessee, Operating Lease, Renewal Term
Net unrealized loss on short-term investments
Net unrealized loss on short-term investments
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Computer equipment and software
Computer Equipment And Software [Member]
Computer equipment and software.
Preferred Stock
Common Stock
Stockholder Rights Agreement
Equity [Text Block]
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Subsequent Event [Table]
Subsequent Event [Table]
General and administrative costs (excluding stock-based compensation)
General And Administrative Expense, Adjusted
General And Administrative Expense, Adjusted
Expiration Date
Trading Arrangement Expiration Date
Construction-in-progress
Construction in Progress [Member]
Schedule of Reconciliation of U.S. Federal Statutory Income Tax Rate to Company’s Effective Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Schedule of Useful Lives of Property and Equipment
Property Plant And Equipment Useful Lives Table [Table Text Block]
Tabular disclosure of property plant and equipment useful lives.
Property and equipment, net (Note 4)
Total property and equipment, net
Property, Plant and Equipment, Net
Auditor Information [Abstract]
Auditor Information
Restructuring charges
Restructuring Charges
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Adoption Date
Trading Arrangement Adoption Date
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Prepaid expenses
Deferred Tax Liabilities, Prepaid Expenses
Restructuring Cost [Table]
Restructuring Cost [Table]
Entity Current Reporting Status
Entity Current Reporting Status
Lease term
Lessee, Operating Lease, Term of Contract
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Loss from operations
Segment loss
Operating Income (Loss)
Percent of outstanding shares, shares added per year to plan
Percent Of Outstanding Shares, Shares Added Per Year To Plan
Percent Of Outstanding Shares, Shares Added Per Year To Plan
Accumulated deficit
Retained Earnings (Accumulated Deficit)
US Federal Statutory Tax Rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Schedule of Classification of Stock-based Compensation Expense
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Gain on sale of property plant and equipment
Gain (Loss) on Disposition of Property Plant Equipment
Amortization (accretion) on short-term investments
Accretion (Amortization) of Discounts And Premiums, Investments And Debt
Accretion (Amortization) of Discounts And Premiums, Investments And Debt
Financial Instrument [Axis]
Financial Instrument [Axis]
Deferred tax assets:
Deferred Tax Assets, Gross [Abstract]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Executive Category:
Executive Category [Axis]
Valuation allowance as a percentage on total deferred tax assets
Valuation Allowance As Percentage On Deferred Tax Assets
Valuation allowance as percentage on deferred tax assets.
Stock Based Compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Payment of debt
Payment of debt
Repayments of Debt
State taxes, net of federal tax benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Current Fiscal Year End Date
Current Fiscal Year End Date
Class of Stock [Axis]
Class of Stock [Axis]
Expected term (in years)
Expected term of options (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
2015 and 2020 Equity Incentive Plans and 2020 Inducement Plan
Two Thousand Fifteen And Two Thousand Twenty Equity Incentive Plans And Two Thousand Twenty Two Inducement Plan [Member]
Two Thousand Fifteen And Two Thousand Twenty Equity Incentive Plans And Two Thousand Twenty Two Inducement Plan
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Proceeds from issuances of common stock under benefit plans
Proceeds From Issuances Of Common Stock Under Benefit Plans
Proceeds From Issuances Of Common Stock Under Benefit Plans
Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Statement [Table]
Statement [Table]
Percentage of payroll deductions
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Cash flows from financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Grant date fair value of stock option (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
Common stock fair market value percentage
Common Stock Fair Market Value Percentage
Common stock fair market value percentage .
January 1
December 31
Unrecognized Tax Benefits
Investment, Type [Extensible Enumeration]
Investment, Type [Extensible Enumeration]
Antidilutive securities excluded from computation of earnings per share (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Exercise price as a percentage of estimated grant date fair value of shares
Share Based Compensation Arrangement By Share Based Payment Award Exercise Price With Purchase Price Of Common Stock Percentage Of Estimated Grant Date Fair Value For Shareholders
Share based compensation arrangement by share based payment award exercise price with purchase price of common stock percentage of estimated grant date fair value for shareholders.
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Amendment Flag
Amendment Flag
Leases
Lessee, Operating Leases [Text Block]
Termination Date
Trading Arrangement Termination Date
Net cash (used in) provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Measure:
Measure [Axis]
Schedule of Assets Held for Sale
Disclosure of Long-Lived Assets Held-for-Sale [Table Text Block]
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Schedule of Option Activity Under the 2015 Plan and 2020 Plan
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Debt Draw Period [Domain]
Debt Draw Period [Domain]
Debt Draw Period [Domain]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Weighted average shares used in computing net loss per share - basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Number of options, exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Subsequent Events [Abstract]
Segment Reporting [Abstract]
Number of rights declared
Dividend Distribution, Number Of Rights Declared
Dividend Distribution, Number Of Rights Declared
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Debt Disclosure [Abstract]
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Entity Tax Identification Number
Entity Tax Identification Number
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Text Block]
Prepaid Expenses And Other Current Assets
Outstanding, beginning balance (USD per share)
Outstanding, ending balance (USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Restructuring and Related Activities [Abstract]
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Common stock, par value (USD per share)
Common Stock, Par or Stated Value Per Share
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Weighted-average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Reportable Segment
Reportable Segment [Member]
Reportable Segment
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Entity Public Float
Entity Public Float
Schedule of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for 2020 Employee Stock Purchase Plan
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Interest expense
Interest expense
Interest Expense, Nonoperating
Trading Arrangement:
Trading Arrangement [Axis]
Total Shareholder Return Amount
Total Shareholder Return Amount
Loan Agreement
Loan Agreement [Member]
Loan Agreement
Subsequent Event
Subsequent Events [Text Block]
Insider Trading Arrangements [Line Items]
Security Exchange Name
Security Exchange Name
Forfeited (USD per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Total liabilities
Liabilities
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Purchase of property and equipment in accounts payable
Capital Expenditures Incurred but Not yet Paid
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Pliant Therapeutics
Pliant Therapeutics [Member]
Pliant Therapeutics
Additions based on tax positions related to current year
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Operating expenses:
Operating Expenses [Abstract]
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
Contractual arrangements cancellation period
Contractual Arrangements Cancellation Period
Contractual arrangements cancellation period.
Other
Deferred Tax Assets, Tax Deferred Expense, Other
Statement [Line Items]
Statement [Line Items]
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Capitalized research and development
Deferred Tax Assets, Capitalized Research And Development
Deferred Tax Assets, Capitalized Research And Development
Cash and cash equivalents
Cash and Cash Equivalent
Counterparty Name
Counterparty Name [Axis]
Schedule of Restricted Stock Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Restructuring Charges, Statement of Income or Comprehensive Income [Extensible Enumeration]
Restructuring Charges, Statement of Income or Comprehensive Income [Extensible Enumeration]
Risk-free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Common Stock
Common Stock [Member]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Non-NEOs
Non-NEOs [Member]
Corporate debt securities
Corporate Debt Securities [Member]
Net (decrease) increase in cash and cash equivalents
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Schedule of Prepaid Expenses and Other Current Assets
Schedule Of Prepaid Expenses And Other Current Assets [Table Text Block]
Schedule Of Prepaid Expenses And Other Current Assets