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Disclosure - Financial Instruments link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Property and Equipment, net link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Prepaid Expenses and Other Current Assets link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Accrued and Other Liabilities link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Novartis Collaboration and License Agreement (the "Novartis Agreement") link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Common Stock link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0000019 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 0000020 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 0000021 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 0000022 - Disclosure - Defined Contribution Plan link:presentationLink link:calculationLink link:definitionLink 0000023 - Disclosure - Net Loss Per Share Attributable to Common Stockholders link:presentationLink link:calculationLink link:definitionLink 0000024 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 0000025 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 0000026 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 0000027 - Disclosure - Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 0000028 - Disclosure - Property and Equipment, net (Tables) link:presentationLink link:calculationLink link:definitionLink 0000029 - Disclosure - Prepaid Expenses and Other Current Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 0000030 - Disclosure - Accrued and Other Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 0000031 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 0000032 - Disclosure - Common Stock (Tables) link:presentationLink link:calculationLink link:definitionLink 0000033 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 0000034 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 0000035 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 0000036 - Disclosure - Net Loss Per Share Attributable to Common Stockholders (Tables) link:presentationLink link:calculationLink link:definitionLink 0000037 - Disclosure - Organization and Description of Business (Details) link:presentationLink link:calculationLink link:definitionLink 0000038 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000039 - Disclosure - Summary of Significant Accounting Policies - Summary of Useful Lives of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 0000040 - Disclosure - Financial Instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000041 - Disclosure - Financial Instruments - Summary of Cash and Cash Equivalents, Money Market Funds and Short-term Investments by Significant Investment Category (Details) link:presentationLink link:calculationLink link:definitionLink 0000042 - Disclosure - Financial Instruments - Summery of Remaining Contractual Maturities of Company's Short-term Investments (Details) link:presentationLink link:calculationLink link:definitionLink 0000043 - Disclosure - Property and Equipment, net - Schedule of Property and Equipment Net (Details) link:presentationLink link:calculationLink link:definitionLink 0000044 - Disclosure - Property and Equipment, net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000045 - Disclosure - Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 0000046 - Disclosure - Accrued and Other Liabilities - Summary of Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000047 - Disclosure - Debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Debt - Schedule of Maturities of Long-Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Novartis Collaboration and License Agreement (the "Novartis Agreement") - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Novartis Collaboration and License Agreement ("the Novartis Agreement") - Performance Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Novartis Collaboration and License Agreement ("the Novartis Agreement") - Performance Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Common Stock - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Common Stock - Schedule of Shares Reserved for Future Issuance (Details) link:presentationLink link:calculationLink link:definitionLink 0000053 - Disclosure - Stock-Based Compensation - Equity Incentive Plan - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000054 - Disclosure - Stock-Based Compensation - Restricted Common Stock Awards - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000055 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Activity (Details) link:presentationLink link:calculationLink link:definitionLink 0000056 - Disclosure - Stock-Based Compensation - Incentive Stock Options and Nonqualified Stock Options - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000057 - Disclosure - Stock-Based Compensation - Summary of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for Stock Option Awards (Details) link:presentationLink link:calculationLink link:definitionLink 0000058 - Disclosure - Stock-Based Compensation - Summary of Option Activity Under the 2015 Plan and 2020 Plan (Details) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Stock-Based Compensation - Restricted Stock Units and Performance-Based Restricted Stock Units - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Stock-Based Compensation - Schedule of TSR PSU Valuation Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Stock-Based Compensation - 2020 Employee Stock Purchase Plan Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Stock-Based Compensation - 2020 Employee Stock Purchase Plan - Summary of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for 2020 Employee Stock Purchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Stock-Based Compensation - Summary of Classification of Stock-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - Disclosure - Income Taxes -Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000065 - Disclosure - Income Taxes - Summary of Reconciliation of U.S. Federal Statutory Income Tax Rate to Company’s Effective Income Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 0000066 - Disclosure - Income Taxes - Summary of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000067 - Disclosure - Income Taxes - Summary of Net Operating Losses and Tax Credit Carry Forwards (Details) link:presentationLink link:calculationLink link:definitionLink 0000068 - Disclosure - Income Taxes - Summary of Changes in Valuation Allowance for Deferred Tax Assets (Details) link:presentationLink link:calculationLink link:definitionLink 0000069 - Disclosure - Income Taxes - Summary of Reconciliation of Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 0000070 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 0000071 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000072 - Disclosure - Leases - Schedule of Operating Lease Liability (Details) link:presentationLink link:calculationLink link:definitionLink 0000072 - Disclosure - Leases - Schedule of Operating Lease Liability (Details) link:presentationLink link:calculationLink link:definitionLink 0000073 - Disclosure - Leases - Weighted-average Remaining Lease Terms and Discount Rates (Details) link:presentationLink link:calculationLink link:definitionLink 0000074 - Disclosure - Related Party Transactions - (Details) link:presentationLink link:calculationLink link:definitionLink 0000075 - Disclosure - Defined Contribution Plan (Details) link:presentationLink link:calculationLink link:definitionLink 0000076 - Disclosure - Net Loss Per Share Attributable to Common Stockholders - Summary of Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 0000077 - Disclosure - Net Loss Per Share Attributable to Common Stockholders - Reconciliation of Numerator and Denominator Used in Calculation of Basic and Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 0000078 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink