Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapeutics that seek to halt progression of fibrotic diseases — ultimately preserving organ function. Our lead product candidate, PLN-74809, is an orally available small molecule designed to be a selective inhibitor of αvβ1 and αvβ6, two integrins that play key roles in multiple fibrotic pathways. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration for both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). We are currently conducting Phase 2a trials of PLN-74809 for the treatment of IPF and PSC. Pliant’s second clinical stage product candidate, PLN-1474, is designed to be a small molecule selective inhibitor of αvβ1, targeting liver fibrosis associated with nonalcoholic steatohepatitis (NASH) and is partnered with Novartis. PLN-1474 has completed Phase 1 testing following the successful completion of this study, PLN-1474 has been transferred to Novartis. In addition to our clinical stage programs, we currently have preclinical programs targeting oncology and muscular dystrophies.
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